Endothelial/pericyte interactions.
Identifieur interne : 007F93 ( Main/Exploration ); précédent : 007F92; suivant : 007F94Endothelial/pericyte interactions.
Auteurs : Annika Armulik [Suède] ; Alexandra Abramsson ; Christer BetsholtzSource :
- Circulation research [ 1524-4571 ] ; 2005.
Descripteurs français
- KwdFr :
- Angiopoïétine-1 (physiologie), Animaux, Calcinose (étiologie), Cellules endothéliales (physiologie), Communication cellulaire, Différenciation cellulaire, Facteur de croissance dérivé des plaquettes (physiologie), Facteur de croissance transformant bêta (physiologie), Humains, Lysophospholipides (physiologie), Muscles lisses vasculaires (physiologie), Protéines membranaires (physiologie), Protéines proto-oncogènes c-sis, Péricytes (physiologie), Récepteur TIE-2 (physiologie), Récepteur au PDGF bêta (physiologie), Récepteurs Notch, Récepteurs aux lysosphingolipides, Sphingosine (analogues et dérivés), Sphingosine (physiologie), Transduction du signal.
- MESH :
- analogues et dérivés : Sphingosine.
- physiologie : Angiopoïétine-1, Cellules endothéliales, Facteur de croissance dérivé des plaquettes, Facteur de croissance transformant bêta, Lysophospholipides, Muscles lisses vasculaires, Protéines membranaires, Péricytes, Récepteur TIE-2, Récepteur au PDGF bêta, Sphingosine.
- étiologie : Calcinose.
- Animaux, Communication cellulaire, Différenciation cellulaire, Humains, Protéines proto-oncogènes c-sis, Récepteurs Notch, Récepteurs aux lysosphingolipides, Transduction du signal.
English descriptors
- KwdEn :
- Angiopoietin-1 (physiology), Animals, Calcinosis (etiology), Cell Communication, Cell Differentiation, Endothelial Cells (physiology), Humans, Lysophospholipids (physiology), Membrane Proteins (physiology), Muscle, Smooth, Vascular (physiology), Pericytes (physiology), Platelet-Derived Growth Factor (physiology), Proto-Oncogene Proteins c-sis, Receptor, Platelet-Derived Growth Factor beta (physiology), Receptor, TIE-2 (physiology), Receptors, Lysosphingolipid, Receptors, Notch, Signal Transduction, Sphingosine (analogs & derivatives), Sphingosine (physiology), Transforming Growth Factor beta (physiology).
- MESH :
- chemical , analogs & derivatives : Sphingosine.
- chemical , physiology : Angiopoietin-1, Lysophospholipids, Membrane Proteins, Platelet-Derived Growth Factor, Receptor, Platelet-Derived Growth Factor beta, Receptor, TIE-2, Sphingosine, Transforming Growth Factor beta.
- etiology : Calcinosis.
- physiology : Endothelial Cells, Muscle, Smooth, Vascular, Pericytes.
- Animals, Cell Communication, Cell Differentiation, Humans, Proto-Oncogene Proteins c-sis, Receptors, Lysosphingolipid, Receptors, Notch, Signal Transduction.
Abstract
Interactions between endothelial cells and mural cells (pericytes and vascular smooth muscle cells) in the blood vessel wall have recently come into focus as central processes in the regulation of vascular formation, stabilization, remodeling, and function. Failure of the interactions between the 2 cell types, as seen in numerous genetic mouse models, results in severe and often lethal cardiovascular defects. Abnormal interactions between the 2 cell types are also implicated in a number of human pathological conditions, including tumor angiogenesis, diabetic microangiopathy, ectopic tissue calcification, and stroke and dementia syndrome CADASIL. In the present review, we summarize current knowledge concerning the identity, characteristics, diversity, ontogeny, and plasticity of pericytes. We focus on the advancement in recent years of the understanding of intercellular communication between endothelial and mural cells with a focus on transforming growth factor beta, angiopoietins, platelet-derived growth factor, spingosine-1-phosphate, and Notch ligands and their respective receptors. We finally highlight recent important data contributing to the understanding of the role of pericytes in tumor angiogenesis, diabetic retinopathy, and hereditary lymphedema.
DOI: 10.1161/01.RES.0000182903.16652.d7
PubMed: 16166562
Affiliations:
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Le document en format XML
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(physiologie)</term><term>Récepteurs Notch</term><term>Récepteurs aux lysosphingolipides</term><term>Sphingosine (analogues et dérivés)</term><term>Sphingosine (physiologie)</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Sphingosine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Angiopoietin-1</term><term>Lysophospholipids</term><term>Membrane Proteins</term><term>Platelet-Derived Growth Factor</term><term>Receptor, Platelet-Derived Growth Factor beta</term><term>Receptor, TIE-2</term><term>Sphingosine</term><term>Transforming Growth Factor beta</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Sphingosine</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Calcinosis</term></keywords><keywords scheme="MESH" qualifier="physiologie" 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Failure of the interactions between the 2 cell types, as seen in numerous genetic mouse models, results in severe and often lethal cardiovascular defects. Abnormal interactions between the 2 cell types are also implicated in a number of human pathological conditions, including tumor angiogenesis, diabetic microangiopathy, ectopic tissue calcification, and stroke and dementia syndrome CADASIL. In the present review, we summarize current knowledge concerning the identity, characteristics, diversity, ontogeny, and plasticity of pericytes. We focus on the advancement in recent years of the understanding of intercellular communication between endothelial and mural cells with a focus on transforming growth factor beta, angiopoietins, platelet-derived growth factor, spingosine-1-phosphate, and Notch ligands and their respective receptors. We finally highlight recent important data contributing to the understanding of the role of pericytes in tumor angiogenesis, diabetic retinopathy, and hereditary lymphedema.</div></front></TEI><affiliations><list><country><li>Suède</li></country><region><li>Svealand</li></region><settlement><li>Stockholm</li></settlement></list><tree><noCountry><name sortKey="Abramsson, Alexandra" sort="Abramsson, Alexandra" uniqKey="Abramsson A" first="Alexandra" last="Abramsson">Alexandra Abramsson</name><name sortKey="Betsholtz, Christer" sort="Betsholtz, Christer" uniqKey="Betsholtz C" first="Christer" last="Betsholtz">Christer Betsholtz</name></noCountry><country name="Suède"><region name="Svealand"><name sortKey="Armulik, Annika" sort="Armulik, Annika" uniqKey="Armulik A" first="Annika" last="Armulik">Annika Armulik</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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